ALS Resources

 

1. Manuscript on EnercelÒ use via Acupuncture Injection Point Therapy in 2 ALS patients has been published in the Journal of Acupuncture and Meridian Studies later this year.

 

click here to download a copy of the publication

Significant Neurological Improvement in Two Patients with Amyotrophic Lateral Sclerosis after 4 Weeks of Treatment with Acupuncture Injection Point Therapy Using Enercel®

Shan Liang DOM*, David Christner MD [MA], PhD**, Stephanie Du Laux D. Ac**, Dariel Laurent MD**

* Center for Acupuncture and Oriental Medicine, Sarasota FL

** World Health Advanced Technologies Ltd., Nassau Bahamas/Sarasota FL

Abstract:

Amyotrophic Lateral Sclerosis (ALS) is a progressive, uniformly fatal, degenerative disorder of upper and motor neurons without any current effective treatment. We report on two case-studies of patients with ALS treated with 4 weeks of Acupuncture injection point therapy using Enercel®. Two patients with advanced ALS were given Enercel® Plus IM 0.25 to 0.5 cc at specific Acupuncture points 5 days per week for 4 weeks. Patient #1 presented with flaccid paralysis of all 4 extremities and impaired speech and swallowing. By week 4, she had significant improvement in motor strength of all 4 extremities, R > L, and improvements in speech and swallowing. She did not continue EnercelÒ Acupoint injections and had slow, progressive loss of neurological function during 3 months of follow-up. Patient #2 had significantly impaired speech and mild motor loss in both upper extremities and left leg. After 4 weeks, his voice had significantly improved to the point that his speech was understandable and his motor function had returned to normal. He continued EnercelÒ Acupoint injections during the 3-month follow-up and the clinical improvement was retained. Thus, two patients with ALS improved after 4 weeks of Enercel® Acupoint injection therapy. Follow-up data suggests that ongoing therapy may be necessary in order to maintain the positive effects. This preliminary data merits further study and confirmation.

2. Clinical Trials:

A. ALS Association [www.alsa.org]

A Randomized, Double-Blind Placebo-Controlled Study of Safety and Efficacy of Botulinum Toxin type B in Sialorrhea in ALS

Assessment of Nutritional Needs in Amyotrophic Lateral Sclerosis

Diaphragm Training (DT) in Amyotrophic Lateral Sclerosis

Effects of a Strengthening Program on Maximum Voluntary Isometric Contraction, Functional Abilities, Fatigue and Quality of Life in Patients with ALS

Emotional Disclosure in Patients with Amyotrophic Lateral Sclerosis: A Randomized, Controlled Trial

Modifying Nutritional Therapy in ALS Patients with Changes in Respiratory Status

Prospective Study of Rapid CT Cerebral Blood Flow Imaging in the Detection of Cognitive Impairment in Sporadic ALS

Prospective Trial of BiPAP Use in Patients with ALS

Randomized Placebo-Controlled Crossover Trial with Delta 9-Tetrahydrocannabinol (THC) for the Treatment of Cramps in Amyotrophic Lateral Sclerosis (ALS)

 

B. Clinicaltrials.gov

1

Recruiting

Genetics of ALS: Identification of Genes With Roles in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) and Amyotrophic Lateral Sclerosis (ALS) With Frontotemporal Dementia

Conditions:

Amyotrophic Lateral Sclerosis;   Familial Amyotrophic Lateral Sclerosis;   Amyotrophic Lateral Sclerosis With Frontotemporal Dementia;   Lou Gehrig's Disease;   Motor Neuron Disease;   Primary Lateral Sclerosis

Intervention:

Other: Genetic study of ALS families

 

2

Recruiting

Safety/Efficacy Study for the Treatment of Amyotrophic Lateral Sclerosis

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Biological: autologous bone marrow-derived stem cells

 

3

Recruiting

Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)

Conditions:

Amyotrophic Lateral Sclerosis;   Lou Gehrig's Disease;   Primary Lateral Sclerosis;   Nervous System Diseases;   Hereditary Spastic Paraparesis

Intervention:

Other: No intervention

 

4

Recruiting

Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis

Condition:

Amyotrophic Lateral Sclerosis

Interventions:

Drug: tauroursodeoxycholic acid (TUDCA);   Drug: Placebo

 

5

Recruiting

Cortex Changes in Real/Imagined Movements in Amyotrophic Lateral Sclerosis (ALS)

Conditions:

ALS;   Amyotrophic Lateral Sclerosis

Intervention:

 

 

6

Recruiting

Olanzapine for the Treatment of Amyotrophic Lateral Sclerosis (ALS) Cachexia

Condition:

Amyotrophic Lateral Sclerosis (ALS)

Intervention:

Drug: Olanzapine

 

7

Recruiting

Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis

Conditions:

Hereditary ALS;   Familial ALS;   Familial Form of Amyotrophic Lateral Sclerosis (fALS);   SOD1 Positive ALS;   Inherited ALS

Intervention:

Drug: Arimoclomol

 

8

Recruiting

EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)

Conditions:

Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease

Intervention:

 

 

9

Recruiting

Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS).

Conditions:

Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease

Intervention:

 

 

10

Recruiting

The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Drug: Memantine

 

11

Recruiting

Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Dietary Supplement: KetoCal Diet

 

12

Recruiting

Clinical Trial Ceftriaxone in Subjects With ALS

Conditions:

Amyotrophic Lateral Sclerosis;   ALS

Interventions:

Drug: ceftriaxone;   Other: placebo

 

13

Recruiting

Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma

Condition:

Melanoma

Intervention:

Drug: ALS-357

 

14

Recruiting

Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) Patient

Conditions:

Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease

Intervention:

 

 

15

Recruiting

Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program

Conditions:

Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease

Intervention:

 

 

16

Recruiting

Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)

Conditions:

Substrate Utilization;   Amyotrophic Lateral Sclerosis;   Neurodegenerative Diseases

Intervention:

 

 

17

Recruiting

Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis (ALS)

Conditions:

Amyotrophic Lateral Sclerosis;   Gastrointestinal Motility

Intervention:

 

 

18

Recruiting

A Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis (ALS)

Interventions:

Drug: E0302 (mecobalamin);   Drug: Placebo

 

19

Recruiting

Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Dietary Supplement: KetoCal

 

20

Recruiting

Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS)

Conditions:

Amyotrophic Lateral Sclerosis;   ALS

Interventions:

Device: BiPAP® S/T System;   Other: sham-NIPPV

 

21

Recruiting

Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population

Conditions:

Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease

Intervention:

 

 

22

Recruiting

A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis(ALS)

Condition:

Amyotrophic Lateral Sclerosis

Interventions:

Drug: Placebo;   Drug: 250 mg CK-2017357;   Drug: 500 mg CK-2017357

 

23

Recruiting

Satisfaction Survey for Amyotrophic Lateral Sclerosis (ALS) Patients Comparing Rooms With and Without Assistive Technology

Conditions:

Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease;   Quality of Life

Intervention:

 

 

24

Not yet recruiting

Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients.

Condition:

Amyotrophic Lateral Sclerosis

Interventions:

Biological: MSC-NTF cells transplantation (i.m.);   Biological: MSC-NTF cells transplantation (i.t.)

 

25

Not yet recruiting

A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients

Condition:

ALS (Amyotrophic Lateral Sclerosis)

Intervention:

Device: Brain Computer Interface (BCI)

 

26

Recruiting

A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis (ALS)

Intervention:

Drug: E0302 (mecobalamin)

 

27

Recruiting

Efficacy and Safety of YAM80 in Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Drug: YAM80

 

28

Recruiting

Combination Therapy in Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Interventions:

Drug: Pioglitazone and Tretinoin;   Drug: Tretinoin and Pioglitazone HCL;   Drug: Placebo

 

29

Recruiting

Feasibility of Telesurveillance and Home Cough Assistance for Amiotrofic Lateral Patients (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Interventions:

Device: Nonin 9500 oxymeter;   Device: In-Exoflator device (Emerson)

 

30

Recruiting

Neuromuscular Transmission in Amyotrophic Lateral Sclerosis

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Procedure: Anconeus Muscle biopsy

 

31

Recruiting

Electrical Impedance Myography as an Outcome Measure in Amyotrophic Lateral Sclerosis Clinical Trials

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

 

 

32

Recruiting

Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

 

 

33

Recruiting

SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)

Condition:

Familial Amyotrophic Lateral Sclerosis

Intervention:

Drug: Pyrimethamine

 

34

Recruiting

Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations

Condition:

Familial Amyotrophic Lateral Sclerosis

Intervention:

Drug: ISIS 333611

 

35

Not yet recruiting

Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Drug: lithium

 

36

Recruiting

High Fat/High Calorie Trial in Amyotrophic Lateral Sclerosis

Condition:

Amyotrophic Lateral Sclerosis

Interventions:

Dietary Supplement: Oxepa;   Dietary Supplement: Jevity 1.5;   Dietary Supplement: Jevity 1.0

 

37

Recruiting

The Pre-Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

 

 

38

Recruiting

Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical Response

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Drug: Cistanche Total Glycosides

 

39

Recruiting

Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)

Conditions:

Amyotrophic Lateral Sclerosis;   Motor Neuron Disease

Intervention:

 

 

40

Recruiting

Nocturnal PtcCO2 Monitoring in Patients With Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic Lateral Sclerosis

Intervention:

Device: PtcCO2

 

3. Patient Letter:

To Whom It May Concern:  

My name is James A. (Andy) Mitchell and I was diagnosed with ALS on March 12, 2010 at the VA Hospital in Houston, Texas.  I am a veteran of the Navy, I participated in Desert Storm and I turned 50 on August 4, 2010. I have always been an active individual. I have always ran, mountain biked, camped, water skied, skateboarded, worked out with weights, ridden motorcycles; been active ALL my life...the only thing that is presently wrong with me - is the ALS. So this has been a difficult adjustment for me to make in my life, BUT I am here to tell you all - the most difficult thing for me is the fact that there is "no hope" for ALS patients. That is IF you follow the medical fields present train of thought.  

                I am also a Christian and I have never accepted that train of thought that the medical field has placed upon my life, nor have I accepted their opinion on what the rest of my life would be like. I have placed my faith in God, and God has blessed me by introducing me to this group of researchers who have taken the same point of view as I have...which is to "NOT" accept the norm just because "it" is the accepted position by the medical field. I have accepted the path that my God has put me on, and I refuse to believe that anyone other than God knows when my time is up here on this earth.    

I was accepted into an ALS research treatment protocol in Sarasota, Florida in July, and went there for the month of July 19th to Aug 13th. This is an "Injection Point Therapy" that utilizes acupuncture and a homeopathic medicine called Enercel. My particular regiment  was established under the direction of the research team of World Health Advanced Technologies and Dr. Shan Liang of Sarasota, Florida.  The treatment consists of approximately 30 injections, 5 times a week, to various points on my body. The treatment took the Dr. 10 minutes a day.   To me personally - it is a small price to pay and there is very little discomfort. The different locations on my body is where the acupuncture comes into play. I have the bulbar type of ALS, so we are primarily focusing on my speech and the muscles in my mouth, and anyone who has been involved with my life...has noticed a drastic improvement in my speech in the first month I have been involved with the treatment. Not only that, I have noticed more control in my mouth and more strength on the left side of my body.  I feel as if I am getting stronger every day.  

 The main thing I want to express is that there "IS" hope for people with ALS...while the "medical field" has already written me and people diagnosed with ALS off...there is hope. I would like to suggest to you all to look at the results of this study, but please act fast...there are many people out there that have been given the same diagnosis as I have, ALS, and have been given no hope. 

 God bless each and everyone one of you, who are making this decision and holding the "hope" of people who are needing that "hope" to be reintroduced into there lives.    

Sincerely,

 James A Mitchell