Studies
Toxicity
of ENERCEL
® in Mice
College of Medicine
Division of Infectious Diseases
University of California Irvine Medical Center
101 The City Drive South
Orange, Ca. 92568
714-456-5134
Darryl
See, MD, Assistant Professor of Medicine
Division of Infectious Diseases
University of California, Irvine
To Whom it May Concern:
1. Objective:
To determine the toxicity of ENERCEL® in mice.
2. Methods: Either placebo (5% ethanol) or ENERCEL®
was administered to groups of 10 adolescent, male CD-I mice. The animals were injected subcutaneously with 0.35 cc of placebo or the active preparation on a daily basis for 28 consecutive days. The animals were observed daily for evidence of gross toxicity (ataxia, lethargy, respiratory distress). After 28 days, sections of harvested brains, kidneys, livers, pancreases and hearts were fixed in 10% formalin, embedded in paraffin, cut by microtome, mounted on slides, stained with hematoxylin and eosin and examined under a light microscope for histopathologic changes.
3. Results: None of the mice manifested any evidence of gross or microscopic toxicity.
Darryl
See, MD
UC Irvine Medical Center
Dept. of Medicine